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What is the relationship among genes, DNA, and chromosomes?
The primary function of a gene is to:
Epigenetic changes can turn genes either on or off (regulate transcriptional activity) without changing the actual DNA.
Which of the following is an adverse prognosticator for AML?
Deletion 13q is an adverse prognosticator in patients with CLL
Match the biomarker to the associated therapeutic agent used in the treatment of AML.
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Venetoclax
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glasdegib
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midostaurin
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azacitidine
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enasidenib
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Match the biomarker to the associated therapeutic agent used in the treatment of CLL
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ibrutinib
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idelalisib
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enasidenib
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giltertinib
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glasdegib
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Clonal evolution of CLL where the malignant lymphocytes develop new genetic lesions leads to:
Match the laboratory method to the correct definition
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Technique that compliments routine chromosomal analysis by use of chromosome-specific DNA probes.
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A staining method to detect antigen distribution within cells or tissue.
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A method for sorting cells based on size, cell surface markers and other characteristics
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A quick, easy method for generating unlimited copies of any fragment of DNA.
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A comprehensive method of reading the genome to identify variants
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Genomic information is increasingly being utilized in cancer care and specifically in hematology. Knowledge of the genomic profile of the individual and of the cancer is leading to improved precision in the diagnosis, treatment and prevention of cancer.